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to Start
Thermochemistry Osmosis
Vigorous
Exercise
Chemical
Reactions - Our Source of Energy
Membrane
Properties and Rehydration
Energy
Deficiency and our Physical Response
Water
Loss and Dehydration
Thermochemistry
of Sugar Metabolism
Formulation
of a Beverage
Gatorade
Testing
of Subjects
Case
Study: Can We Do a Medical Experiment
Who
Owns Gatorade
Case Study: Who Owns Gatorade
When
Rules Change
Stokeley's
Response
Case:
When Government Regulations Intervene
Sports
Science
Rehydration
Energy
Replacement
Quiz
Problems
Micro/Macro
and Symbolic
Representation
We will see below a
molecular model of a molecule of the sweetener,
cyclamate.
This is a 'ball and stick
model, one in which different
atoms are designated by balls of different colors.
The sticks
show the relative distances between the atoms.

Color code:
grey=carbon
white=hydrogen
blue=nitrogen
red=oxygen
yellow=sulfur
| Try to write down
the structure of cyclamate from this ball and
stick model. Use C for carbon, H for hydrogen, O
for oxygen, N for nitrogen, S for sulfur and
solid lines for bonds between atoms. Can you do
it? Can you
see that this representation of a molecule is far
different than that shown by the equations in the
section on sugar metabolism?
What new
information about a molecule can we get from a
ball and stick model that we cannot get from the
formulas in sugar metabolism?
|
|
Dr. Robert Cade's group at the University of Florida understood their
football coaches had tried orange
juice or a sugar-containing soft drink to quench the thirst and supply
fluids during summer football practice. Orange juice and
soft drinks offer taste and tang; most people like to
drink them. We might expect juice or soft drinks would
function well to provide rehydration during exercise. But
two things happened. The athletes felt full, the
beverages didn't seem to slake their thirst. And if they
drank too much juice or soft drink, many of the
exercising athletes felt ill. They suffered the
inconvenience of vomiting and diarrhea.

|
Dr. Cade and his associates began
with the salt solution used for intravenous
replacement of fluids in the body. Then they
added glucose for energy. Glucose is the sugar
that provides energy most rapidly but is not
sweet. A few athletes tried this concoction
but reported it was undrinkable. |
The
physicians quickly learned that they would have to
combine the energy-producing sugars and the salts in a
beverage that was enjoyable to drink. That it would do no
good if their composition was suitable to provide energy
and replenish salts but was not palatable to the athlete
in the course of his or her exercise. Generally,
we are attracted to beverages that are cold, have some
sweetness but are tart, with the bite of citrus. We
add a slice of lemon or lime to many beverages to get
this effect
So the
doctors reformulated their beverage. They added the
artificial sweetener, cyclamate to the
formulation. And finally, they chose to incorporate some
citric acid -- the chemical responsible for the tartness
of citric juices.
| Cyclamate artificial
sweetener was discovered in 1937. As we will soon
see, it was banned from use in beverages in the United States in 1970
because of testing that linked the substance with
cancer in test animals. Nevertheless, the
compound is made for consumption in other parts
of the world |
The reformulated composition contained a
slightly higher concentration of dissolved particles per
liter that we find in the body. The inventors
reasoned most athletes would put ice in the drink and
dilute it down to the approximate concentration of body
fluid.
This
formulation worked. Athletes would drink it.
It provided energy and salt replenishment. The invention
became Gatorade®, after the
tremendous aid it had provided University of Florida,
whose team mascot is the (alli)Gator.
Chemical
Concepts
The
formulation of Gatorade® depended on detailed
consideration of the properties of near-isotonic
solutions.
| 8. Isotonic
Solutions |
are |
Solutions Containing the
Same Concentration of Particles |
| Essential in Human Sysytems
to Prevent Cell Crenation (Shriveling) or
Hemolysis (Swelling) |
| Difficult to Maintain in the
Exercising Athlete |
Try to
relate these concepts to the relationship of exercise,
dehydrationand fatigue that we discuss in the
accompanying unit.
|