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Phenobarbitol and Human Acid-Base Chemistry

Prof. Sally Boudinot

Epilepsy, Its Treatment, and the Role of Phenobarbital

Epilepsy is a chronic neurologic disorder characterized by seizures. Unlike many diseases, epilepsy affects all demographic groups equally, with about 1% of the American population diagnosed with the disease. The most common age for seizures to begin is between the ages of 5 and 20 years, but the onset may be much later in life.

As with many disease conditions, the Internet affords an opportunity for the dissemination of detailed information including the history of the disease, whom it effects, the diagnosis, symptoms, treatment and outlook.  If you are interested in epilepsy you might look at this epilepsy Frequently Asked Questions (FAQ) site

Seizures result from an abnormal electrical impulse in the brain. People with epilepsy find that seizures are often initiated by specific stimulations - lack of sleep, emotional stress, menstruation, alcohol ingestion and the presence of flickering lights.  The seizures may last from seconds to minutes, with the cause for most seizures unknown.

There are several ways to treat seizures associated with epilepsy. Most treatment regimens begin with drug therapy, but other treatments may include diet modification and even surgery. Careful monitoring of medication level and compliance to the drug regimen prescribed by the physician can usually result in the patient leading a relatively normal life. New developments have led to a greater success in therapy. 

Phenobarbital affects many organs of the body and not just the central nervous system.  Phenobarbital stabilizes the membranes of the nerves, preventing the conduction of the signal. If you think of the nervous system as similar to electricity, then phenobarbital stops the conduction of the "electric signal" to the brain.

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Case Study in Phenobarbitol
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Principal Investigator
Laurence I. Peterson, Dean
College of Science and Mathematics
Kennesaw State University
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Kennesaw, GA 30144-5591
770-423-6160
FAX 770-423-6530
email
lpeterso@kennesaw.edu

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Matthew E. Hermes
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843-322-0486

email hayden@islc.net

Prof. Sally Boudinot
College of Pharmacy
University of Georgia
Athens, GA
sallyb@rx.uga.edu